Dehydration drugs eliminate nerve root inflammation

Neurological diseases are very common in life and can have a great impact on people's lives, because nerves are the most important tissues in the body, the sensory pathways that control body behavior, and the only way for the brain to control various tissues throughout the body through nerves. However, neurological diseases hinder the normal realization of this function. For example, nerve root inflammation is a relatively serious disease. Let’s take a look at the effectiveness of using dehydration drugs to eliminate nerve root inflammation.

The spinal nerve roots do not have the epineurium and perineurium, and compared with peripheral nerves, they lack chemical barrier function and have a lower ability to tolerate chemical stimulation. Its blood supply lacks nerves and two groups of vascular networks within the perivascular membrane, making it prone to inflammation and edema. Studies have shown that the inflammatory mediator SP can directly act on the microcirculation and cause plasma extravasation, and can also indirectly dilate blood vessels by promoting the release of histamine, increasing blood flow and tissue congestion and edema. Both VIP and CGRP have the effects of vasodilation and inflammatory exudation, and venous congestion quickly leads to spinal nerve root edema. The study also found that spinal nerve root inflammatory edema lasts for a long time, and endoneurium edema will lead to fibrosis and degeneration of nerve tissue. Compared with edema caused by compression, the mechanism of spinal nerve root inflammatory edema is not well studied, and there is no literature report on the possible relationship between the two. In addition, the traction during lumbar disc herniation surgery and the stimulation of surrounding inflammatory exudate may also aggravate the inflammation of the spinal nerve roots.

Hypertonic magnesium sulfate (12.5%) has the effects of dehydration, improving microcirculation, and regulating the balance of potassium and calcium ions inside and outside cells. Guan Chunhe et al. achieved good results with epidural injection. Intravenous injection of mannitol not only reduces edema, but also, as it is an oxygen free radical antagonist in the body, it can reduce the secondary damage to the spinal nerve roots caused by the massive production of oxygen free radicals due to surgery.

Lidocaine can dilate blood vessels and improve local blood circulation. When 2% lidocaine is injected around the spinal ganglia or paravertebral sympathetic ganglia, the blood flow of the spinal ganglia is measured to be significantly increased, thereby promoting blood circulation and reducing edema. Solanum alkaloids such as 654-2 also have similar effects. Other Chinese herbal preparations with similar effects include compound danshen liquid and pit viper antacid enzyme. Its epidural injection has the effects of promoting blood circulation, removing blood stasis, dredge meridians, promote qi circulation and relieve pain. However, some authors believe that Chinese medicine has complex ingredients and may have serious consequences if it penetrates into the subdural space.