How to diagnose early Parkinson's disease?

The health of the elderly is very vulnerable to damage because their body functions are gradually aging, which causes their body resistance to decrease and their various functions to gradually weaken, causing great damage to the body. Among them, most of the elderly diseases are unique to middle-aged and elderly people. For example, Parkinson's syndrome is a disease with a great impact. Let's take a look at how to diagnose early Parkinson's disease?

1. Serum renin activity decreased, tyrosine content decreased; NE and 5-HT content in the substantia nigra and striatum decreased, and glutamate decarboxylase activity decreased by 50% compared with the control group.

2. Biochemical detection and radioimmunoassay showed that the content of somatostatin in CSF was decreased. DA and its metabolites 3-methoxytyramine, 5-HT, adrenaline and NE in urine also decreased.

3. CT and MRI imaging manifestations: Since Parkinson's disease is a degenerative disease of the central nervous system, the pathological changes are mainly in the substantia nigra, striatum, globus pallidus, caudate nucleus and cerebral cortex. Therefore, in addition to generalized brain atrophy, CT imaging manifestations sometimes show basal ganglia calcification. In addition to showing manifestations of brain atrophy such as ventricular enlargement, MRI T2-weighted images often show multiple high-signal spots in the basal ganglia and white matter.

4. SPECT imaging manifestations

(1) Functional imaging through dopamine receptors: Dopamine receptors are widely distributed in the dopaminergic pathways of the central nervous system, mainly in the substantia nigra and striatum systems, distributed in the cell bodies of striatal non-cholesterol interneurons; located in the cell bodies of dopaminergic neurons in the substantia nigra and striatum.

(2) Through dopamine transporter functional imaging: It is still unclear how the dopamine transporter transports dopamine. DAT is mainly distributed in the basal ganglia and thalamus, and secondly in the frontal lobe. There is a positive correlation between the content and the severity of Parkinson's disease, and the basal ganglia are reduced, which is very obvious in patients with early Parkinson's disease.

The presence of atypical symptoms and signs that do not support the diagnosis of primary Parkinson's disease, such as pyramidal tract signs, apraxic gait disorders, cerebellar symptoms, intention shock, gaze palsy, severe autonomic dysfunction, and obvious dementia with mild extrapyramidal symptoms.