What is Leucine Aminotranspeptidase?

Leucine aminotranspeptidase is a protease in the human body and a body tissue inside the human body. This protease is relatively critical to the human liver. If the level of leucine aminotranspeptidase is too high, it will easily lead to diseases such as hepatitis or liver cancer. Leucine aminotranspeptidase is a protease that is a relatively critical tissue for the body.

What is Leucine Aminotranspeptidase?

LAP is a protease that is abundant in the liver. When there is extrahepatic or extrahepatic bile stasis, LAP activity increases significantly, especially in malignant bile stasis, and its activity continues to increase with the progression of the disease. The reagent is valuable for the diagnosis of hepatic tract obstruction and pancreatic cancer. Liver gangrene, liver tumors, hepatitis, breast cancer, liver cancer, bile duct cancer, pancreatic cancer, endometrial cancer, and ovarian cancer have increased significantly.

Cirrhosis and infectious hepatitis may increase moderately, often 2-4 times the reference value. Obstructive jaundice increases significantly, often reaching more than 5 times the reference value, and appears before the increase of bilirubin or ALP.

Unlike other liver function enzymes, which can only be tested in blood samples, LAP can also be tested in urine. In some cases, changes in LAP can be detected in the urine without the need for a blood sample. Leucine aminopeptidase (LAP) LAP is widely present in various tissues of the human body. When toxic substances or diseases affect the proximal tubules rich in LAP, the activity of urinary LAP is highest.

LAP increases when the permeability of the glomerular basement membrane increases, tubular epithelial cells are damaged, drug-induced toxic nephropathy occurs, and renal tumors occur. Increased urinary LAP after tumor treatment indicates tumor recurrence. An analysis of various renal cases revealed that LAP had the highest positivity rate.

Normal range

Normal serum leucine aminotransferase (LAP) values:

(1) Enzyme rate method (37°C):

Male: 18.3～36.7U/L.

Female: 16.3～29.2U/L.

(2) Chromogenic method: 27~50U/L.

Clinical significance

Elevated: bile duct cancer, pancreatic cancer, or gallstones causing extrahepatic obstruction, drug-induced liver damage, viral hepatitis, intrahepatic bile stasis, acute hepatitis, malignant lymphoma, lymphosarcoma, pregnancy, liver metastasis without jaundice, etc.