The main effects of chloramphenicol ointment

Chloramphenicol ointment is an external ointment, which is mainly applied to people's skin. In this way, it can play an anti-inflammatory and bactericidal role. It has a great therapeutic purpose for some diseases caused by bacteria, fungi, etc. It can control the development of the disease in a short time, and the side effects are very low. It basically will not cause a very big impact on your body, so it can be applied for a long time.

This product is a chloramphenicol antibiotic. It has a broad-spectrum antimicrobial activity in vitro, including aerobic Gram-negative and Gram-positive bacteria, anaerobes, Rickettsia, spirochetes and Chlamydia. It has bactericidal effect on the following bacteria: Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis. It only has an antibacterial effect on the following bacteria: Staphylococcus aureus, Streptococcus pyogenes, Streptococcus viridans, group B hemolytic Streptococcus, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Salmonella typhi, Salmonella paratyphi, Shigella, Bacteroides fragilis and other anaerobic bacteria. The following bacteria are commonly resistant to chloramphenicol: Pseudomonas aeruginosa, Acinetobacter spp., Enterobacter spp., Serratia marcescens, indole-positive Proteus spp., methicillin-resistant Staphylococci, and Enterococcus spp.

This product is an antibacterial agent. Chloramphenicol is fat-soluble and enters bacterial cells by diffusion, and reversibly binds to the 50S subunit of the bacterial ribosome, which blocks the growth of the peptide chain (possibly due to the inhibition of the action of transpeptidase), thereby inhibiting the formation of peptide chains and preventing protein synthesis.

Chloramphenicol was once widely used to treat various sensitive bacterial infections. Later, due to its serious adverse reactions on the hematopoietic system, its clinical application is now strictly controlled. It can be used for typhoid, paratyphoid, rickettsial diseases, etc., where it has specific effects, as well as severe infections caused by sensitive bacteria. Chloramphenicol, which is present in high concentrations in cerebrospinal fluid, is also often used to treat meningitis in patients who are refractory to other drugs. If necessary, the drug can be administered by intravenous drip. Because chloramphenicol can cause serious toxic side effects, it is clinically only used for typhoid infection caused by sensitive typhoid strains, influenza bacillus infection, severe Bacteroides fragilis infection, brain abscess, Streptococcus pneumoniae or meningococcal meningitis in patients who are allergic to penicillin. When using this product, avoid long courses of treatment. Patients with a history of drug-induced hematological abnormalities should not use this product.