What is the reason for high dimer level

In order to ensure normal blood circulation in the human body. The plasmin and lipase in the blood will always maintain a dynamic balance, which can enhance the permeability of the blood vessel wall and maintain normal blood circulation. When the patient suffers trauma or blood vessel damage, blood clots will form, and coagulation factors will be formed. That is to say, under the action of thrombin, dimers can be formed. This is also an indicator of this common medical examination. When the dimer is significantly increased, it reflects that the coagulation factors in the blood are gradually enhanced, which can easily induce some thrombotic diseases and lead to the occurrence of some cardiovascular diseases, the more common of which are cerebral infarction, myocardial infarction, etc.

High Dimer Causes

1. Consider the possibility of intercostal neuralgia or costal cartilage inflammation. For the time being, you can take oral ibuprofen, indomethacin, and amoxicillin for the symptoms. If necessary, further examination and testing are needed to confirm the diagnosis and take comprehensive measures for treatment according to the specific situation.

2. Theoretically, the gold standard for confirming and excluding pulmonary embolism is pulmonary artery angiography. If the blood D-dimer is not high, it may indicate that pulmonary embolism is unlikely.

Suggestions: 1. Check the blood D-dimer. If it is significantly elevated, it indicates a high possibility of pulmonary embolism. 2. Perform a chest CF examination. An experienced CT diagnostic expert can make a judgment from the mediastinal window.

3. Myocardial infarction, cerebral infarction, pulmonary embolism, venous thrombosis, surgery, tumors, disseminated intravascular coagulation, infection and tissue necrosis can all lead to elevated D-dimer levels. Especially for the elderly and hospitalized patients, diseases such as bacteremia can easily cause coagulation abnormalities and lead to elevated D-dimers. So you have ruled out cerebral embolism and myocardial infarction, but there is still a possibility that pulmonary embolism will increase.

Clinical significance

1. D-dimer originates from cross-linked fibrin clots dissolved by plasmin and mainly reflects the fibrinolytic function. The clinical detection of D-dimer is mainly used in the diagnosis of venous thromboembolism (VTE), deep vein thrombosis (DVT) and pulmonary embolism (PE).

2. Increase: seen in secondary hyperfibrinolytic function, such as hypercoagulable state, disseminated intravascular coagulation, kidney disease, organ transplant rejection, thrombolytic therapy, etc.

3. Myocardial infarction, cerebral infarction, pulmonary embolism, venous thrombosis, surgery, tumors, disseminated intravascular coagulation, infection and tissue necrosis can also lead to elevated D-dimer levels.