Can you get pregnant if you have positive anti-sperm antibodies?

Antisperm antibodies are a relatively complex substance. Both men and women may have such antisperm antibodies. When antisperm antibodies are positive, it can easily lead to female infertility, which can be clearly detected in laboratory test data. If a woman's cervical mucus contains anti-sperm antibodies, sperm will not be able to pass through easily when they gather and will not be able to form a fertilized egg.

Does positive anti-sperm antibodies affect pregnancy?

1. Studies have found that 15.18% of infertile women have anti-sperm antibodies in their bodies. Under normal circumstances, sperm and embryos are foreign bodies to the mother. The appearance and increased titer of antisperm antibodies can lead to infertility in both men and women. Therefore, the detection of AsAb can be used as an important indicator for clinical treatment and prognosis of infertile patients. Positive antisperm antibodies affect pregnancy!

2. Semen is composed of sperm and seminal plasma, in which more than 30 antigens have been discovered. Under normal circumstances, sperm and seminal plasma are isolated from the body's immune system by the blood-testicular barrier and do not produce antibodies. However, under pathological conditions, semen can act as an antigen, causing the body to produce antibodies, resulting in an antigen-antibody reaction.

3. The result of men’s autoimmune response is that, on the one hand, cellular immunity leads to orchitis, causing azoospermia or oligospermia. On the other hand, it produces sperm agglutination and sperm braking antibodies, which are distributed in plasma and seminal plasma, reducing the survival rate and motility of sperm, greatly reducing the quality of semen, inhibiting sperm adhesion and penetration of the zona pellucida of the egg, and preventing sperm and egg combination. In addition, antisperm antibodies can act on the embryo to cause it to be absorbed or cause miscarriage, and interfere with the fertilization process in many ways, leading to infertility.

4. When anti-sperm antibodies exist in a woman's cervical mucus, they cause sperm to agglutinate and hinder their passage through the mucus, damaging the sperm and enhancing the function of macrophages to phagocytize sperm, preventing the sperm from entering the fallopian tube and causing infertility. This is caused by the allogeneic immune response that occurs when semen enters the woman's body through her damaged reproductive organs during sexual intercourse.

What to do if anti-sperm antibodies are positive

1. Immunosuppressive therapy:

Immunosuppressive therapy mainly uses various types of adrenal cortical hormones to treat the symptoms of immune infertility. According to the female's physiological cycle, the time of ovulation is estimated, and the trial begins two weeks before the ovulation cycle. It can have a local hydrogenation effect on the female's cervical mucus and vagina, greatly improving the female's pregnancy rate.

2. Intrauterine artificial insemination

Intrauterine artificial insemination is mainly aimed at anti-sperm antibodies caused by the condition of cervical mucus. The best way to deal with cervical mucus is to use artificial insemination. The husband's semen is taken out, and the sperm of good quality is taken out. After separation, it is placed in the female's uterine cavity.