Brain protein denaturation

The brain is the command center of the human body. All body commands are issued through the brain. Therefore, the brain is an extremely important part for people. However, due to the adverse changes in various factors in modern life, brain diseases are becoming more and more common, causing great health hazards to people. For example, brain protein denaturation is one of the common problems. Let’s take a look at what happens when brain protein denaturation occurs.

White matter is the area inside the brain where nerve fibers gather. It is named white matter because its color is lighter than the surface of the brain where cell bodies gather. If the myelin sheath of central nervous cells in the white matter of the brain is damaged, it will cause white matter disease. White matter disease is a structural change of the brain, characterized by damage to the myelin sheath of central nervous cells. The lesions involve the white matter tracts that are specialized for higher brain functions. Its clinical manifestations range from inattention, forgetfulness and personality changes to dementia, coma and even death.

White matter disease is a group of demyelinating diseases of the central nervous system whose specific etiology is still unclear. It can be a secondary manifestation of neurological diseases such as infection, poisoning, degeneration, trauma, infarction, etc. The main suspected causes include:

1. Genetic factors: Among white European and American multiple sclerosis patients, many are positive for HLA-A3, -B7 and -DW2 antigens; and patients with metachromatic leukodystrophy have an autosomal recessive genetic disease.

2. Human geographical factors: Multiple sclerosis is more common in cold temperate zones and less common in tropical zones. The incidence rate is high in Europeans, but low in Orientals and Africans.

3. Infectious factors: Measles virus, herpes virus and HIV virus are suspected to be related to multiple sclerosis. It has been proven that JC virus of the Papovaviridae family and SV-40 (Simian Virus monkey virus) are the pathogens of progressive multifocal leukoencephalopathy. The medical community generally recognizes that subacute sclerosing panencephalitis is caused by measles virus.

4. Poisoning: White matter disease caused by a variety of toxic factors include cranial irradiation, drug treatment, such as certain anti-tumor drugs, antibiotics and immune preparations, drug abuse, such as toluene, ethanol, heroin, etc., and environmental toxins.

5. Vascular diseases: They are the most common in adults (especially the elderly), and clinically they often have a history of hypertension and arteriosclerosis, accompanied by repeated multiple infarctions and cerebral atrophy.

6. Adrenoleukodystrophy: It is most common in children and more common in men aged 20 to 30 in adults. It can cause adrenal insufficiency, sexual dysfunction, cerebellar ataxia and intellectual impairment.