The reasons for the low neutrophil percentage are actually these 7 points

When people have a routine blood test, they are often told by their doctors that their neutrophil percentage is low. However, doctors usually do not tell patients what causes the low neutrophil percentage in daily life. In fact, there are seven reasons that can cause low neutrophil count, and the primary factor is infection with Gram-negative bacteria.

1. Causes of low neutrophil count

1. Gram-negative bacillus infection, such as typhoid and paratyphoid.

2. Certain viral infections, such as influenza virus.

3. Chronic physical and chemical damage, long-term exposure to lead, mercury, benzene, etc.; certain drugs such as chloramphenicol and synnomycin; patients who have received long-term radiation and chemotherapy.

4. Autoimmune diseases such as systemic lupus erythematosus.

5. Blood diseases such as aplastic anemia (AA).

6. Hypersplenism and hyperthyroidism.

7. Certain parasitic diseases such as malaria and kala-azar.

2. The harm of low neutrophil count

Low neutrophil count can lead to bone marrow dysplasia, bone marrow invasion (leukopoietic proliferation of oligodendrocytes, partial myeloblastic leukemia), viral infections, typhoid fever, paratyphoid fever, certain parasitic diseases (malaria, kala-azar), hyperthyroidism, hypersplenism, Waldenstrom's disease, multiple myeloma, Felty's syndrome, anemia (iron deficiency, folic acid deficiency, vitamin B12 deficiency), radiation (e.g., localized therapy), agranulocytosis (poisoning: pilamidol, phenothiazines, phenylbutazone, antithyroid drugs, etc.; immune-immunoallergic diseases; systemic diseases).

3. What to do if neutrophil count is low

Generally speaking, neutrophils originate from hematopoietic stem cells in the bone marrow, differentiate and develop in the bone marrow, and then enter the blood or tissues. The distribution ratio in bone marrow, blood and connective tissue is 28:1:25. The number of neutrophils in adult blood accounts for about 55% to 70% of the total white blood cells. Neutrophils are a type of polymorphonuclear leukocytes. Since their number is the largest among granulocytes, some people refer to polymorphonuclear leukocytes as neutrophils.

The cells contain many diffusely distributed tiny light red or light purple unique granules, which contain myeloperoxidase, acid phosphatase, phagocytosis, lysozyme, etc. Myeloperoxidase is unique to neutrophils and is present in very low or no amounts even in macrophages, which have a strong phagocytic ability. In cytochemistry, myeloperoxidase is generally used as a marker for neutrophils.

Neutrophils have a strong chemotactic effect. Chemotaxis is the movement of cells toward the direction stimulated by a chemical substance. Substances that have a chemotactic effect on neutrophils are called neutrophil chemotactic factors. There are chemokine receptors on the cell membrane of neutrophils. The receptors bind to chemokines, activating the calcium pump on the cell membrane. The cell extends its lamellae forward, causing the cell to move toward the site where the chemokine is produced.