What are the reasons for high thyroid antibodies

The disease of high thyroid antibodies is very common in life, and many of the causes are caused by the patient's lifestyle habits. High thyroid antibodies are antibodies produced by thyroid autoimmunity, which have a great impact on the health of the body. Therefore, patients with high thyroid antibodies generally pay close attention to their eating habits.

Thyroglobulin antibody (TGAb) is a common autoantibody in the serum of patients with autoimmune thyroid disease. Hyperthyroidism is a very common thyroid disease also known as hyperthyroidism. This disease has a great impact on the patient's physical health, and seriously endangers the patient's normal life, and even endangers the life of the hyperthyroidism patient. Therefore, you should go to a regular hospital for treatment as soon as possible.

Thyroglobulin antibody is a common autoantibody in the serum of patients with autoimmune thyroid disease. It is mainly composed of IgG1, IgG2 and IgG4, with a small amount of IgA and IgM. It is generally believed that TGAb has no damaging effect on the thyroid gland. After TGAb binds to thyroglobulin, it can interact with the bound antibody through Fc receptors to activate NK cells, attack target cells, and cause thyroid cell destruction.

TGAb also affects the uptake and processing of TG antigens and catalyzes TG hydrolysis, thereby affecting the autoimmune response of non-significant T cell antigenic determinants, thereby leading to the deterioration of autoimmune thyroid disease. Normal value of thyroglobulin: 11.4～20.2mg/L. You said it was as high as 400. I suggest you still need to continue treatment and examination.

Common clinical manifestations of hyperthyroidism:

(1) Abnormalities in energy metabolism and sugar, protein, and fat metabolism: In hyperthyroidism, the basal metabolic rate (BMR) increases, which may lead to hot flashes, sweating, weight loss, low work efficiency, muscle wasting, weakness, fatigue, negative balance of protein metabolism, decreased or normal cholesterol, disappearance of subcutaneous fat, accelerated fat metabolism, increased breakdown of liver and muscle glycogen, accelerated glycogenolysis, increased blood sugar or postprandial hyperglycemia. Severe abnormalities in sugar metabolism may lead to diabetes.

(2) Disorders in water, salt and vitamin metabolism: Thyroid hormones can promote diuresis and excrete potassium and magnesium. Therefore, hypokalemic periodic paralysis and hypomagnesemia are prone to occur in hyperthyroidism. The circulation of calcium and phosphorus is accelerated, and there is often high urine calcium, high urine phosphorus and high urine magnesium. Over time, bone decalcification and osteoporosis, as well as multiple vitamin deficiencies such as vitamin B1, C, D and trace element deficiencies may occur.

(3) Symptoms of abnormal skin and muscle metabolism: negative metabolic balance of protein, negative balance of creatine, negative balance of nitrogen, decreased ATP, decreased creatine phosphate, prone to hyperthyroid myopathy, eye muscle weakness, myasthenia gravis, or frequent flaccid paralysis, myxedema of the skin, more common on the eyelids and anterior tibia, softening or deformation and infection of nails.