What is primary amyloidosis

What is primary amyloidosis? Primary amyloidosis is actually the appearance of petechiae and purpura on the skin surface after mild trauma. This disease can occur in both male and female friends. The general age of onset is over 60 years old and it commonly occurs in the elderly. So we should understand what primary amyloidosis is and what its characteristics are.

Primary systemic amyloidosis is also known as Lu-Pitt disease, Lu-Pitt disease, and primary systemic amyloidosis. Early specific manifestations are carpal tunnel syndrome, skin and mucosal lesions, hepatomegaly and macroglossia.

Early specific manifestations are carpal tunnel syndrome, skin and mucosal lesions, hepatomegaly and macroglossia. Macroglossia is seen in 12% to 40% of patients. Due to the enlargement of the tongue, there may be tooth marks on both sides. The surface of the tongue may be smooth and dry, or there may be waxy papules, nodules, plaques, bullae, fissures, ulcers and bleeding, and some may be accompanied by painful dysphagia.

Early skin symptoms are petechiae, ecchymoses and purpura following mild trauma or spontaneously, which often occur in wrinkled and sunken areas such as the eyelids, nasolabial folds, neck, axillae, umbilicus, external genitalia and oral cavity. Characteristic skin lesions are asymptomatic smooth, waxy papules, nodules, and plaques that are normal skin color, amber, or yellow and often have a bleeding tendency. The sites of occurrence are similar to those of purpuric lesions and may also involve the periauricular area, central area of ​​the face, buccal mucosa, and groin. The rash may be isolated but may also coalesce into large bumps, giving the face a lion-like appearance.

In addition, there are scleroderma-like lesions on the face, hands, and feet, myxedema-like lesions on the eyelids, lips, and auricles, annular or patchy alopecia or alopecia universalis on the head, waxy infiltrations with hemorrhage and hyperkeratosis and porphyria tarda-like lesions on the palms, various nail dystrophic changes such as brittle nails, absent nails, subungual stripes, lichen planus-like lesions on the nails, and hemorrhagic or pemphigoid-like lesions on the skin and mucous membranes. If the skeletal muscles are affected, back pain may occur, and if the heart and kidneys are affected, heart failure, proteinuria, and renal failure may occur. Some patients experience vomiting blood or bloody stools, and about 20% of patients eventually develop multiple myeloma and experience symptoms such as bone pain.

Through the above introduction, everyone should know what primary amyloidosis is. If there are elderly people around you suffering from primary amyloidosis, you should take them to the hospital for further examination in time to avoid worsening of primary amyloidosis.