What tests should be done for antiphospholipid antibody syndrome

People often refer to antiphospholipid antibody syndrome, which is clinically called antiphospholipid antibody syndrome. The harm of this disease is relatively serious. It not only causes habitual miscarriage in women, but may even cause some skin diseases, such as lupus erythematosus. Therefore, knowing what tests can be done to detect antiphospholipid antibody syndrome can help us detect whether the disease occurs early. The specific antiphospholipid antibody syndrome test methods are as follows:

Antiphospholipid syndrome (APS) is a general term for a group of clinical signs caused by antiphospholipid antibodies (APL antibodies). APL antibodies are a group of antibodies that can react immune to a variety of antigenic substances containing phospholipid structures, mainly including lupus anti-coagulant (LA), anti-cardiolipid antibody (ACL antibody), anti-phosphatidic acid antibody and anti-phosphatidylserine antibody.

Inspection method

1. Syphilis serum false positive test (BFP-STS) and VDRL test The positive rate of BFP-STS test in lupus or other connective tissue diseases is 5% to 19%. The main antigen components of these two tests are a mixture of cardiolipin, phosphatidylcholine (lecithin), and cholesterol, so the sensitivity and specificity of these two test methods for thrombosis are not high.

2. Lupus anticoagulant (LA) Kaolin agglutination time (KCT) is a more sensitive method in LA screening test and is of great significance for the detection of LA substances during pregnancy.

3. Antiphospholipid antibodies, anti-cardiolipin antibodies APL antibodies such as LA, ACL antibodies, etc. are positive, and their titers are high, which has greater clinical significance. Several international standardization seminars have developed a unified ELISA procedure for detecting APL, which can quantitatively or semi-quantitatively determine the IgG, IgA, and IgM classes of APL. It is now recommended to express APL test results as negative, low, moderate, and highly positive to improve the consistency and repeatability of test results among laboratories.

This is the end of this article on what tests to do for antiphospholipid antibody syndrome. In addition, we need to remind all friends that the disease must be diagnosed and treated early to have a good treatment effect. Once the disease is discovered, you must pay attention to changing bad living habits and pay attention to having a good life routine and eating habits. Only in this way can you get rid of the harm of antiphospholipid antibody syndrome as soon as possible.