Human immunoglobulin

When it comes to human immunoglobulin, I believe that most people don’t know much about it. In fact, the main components of human immunoglobulin are glucose, sodium chloride, and even glycine and other ingredients. Human immunoglobulin can be used to treat diseases such as measles and infectious hepatitis, but you must pay attention to its usage and dosage when using it, otherwise it may easily lead to some adverse symptoms. So what is the usage and dosage of human immunoglobulin?

In fact, human immunoglobulin is a very effective drug, but it is not suitable for patients who are allergic to immunoglobulin or have a history of other serious allergies. Below we will give you a detailed introduction to the usage and dosage of human immunoglobulin, as well as the precautions when using it.

Human immunoglobulin

Human immunoglobulin is made from fresh plasma from healthy blood donors or frozen plasma with a shelf life of no more than 2 years. Each batch should be mixed with the plasma of at least 1,000 healthy blood donors. The immunoglobulin components are extracted by segmented precipitation using the low-temperature ethanol protein separation method, and are obtained through ultrafiltration or freeze-drying, dealcoholization, concentration and virus inactivation. The purity of the immunoglobulin should not be less than 90%. Then prepare a solution with a protein concentration of 10%, add an appropriate amount of stabilizer, sterilize and filter, and aseptically fill.

Human immunoglobulin ingredients: The active ingredient of this product is human immunoglobulin, and the excipients are glucose, polysorbate 80, sodium chloride, glycine, and water for injection.

Indications: Mainly used to prevent measles and infectious hepatitis. If used in combination with antibiotics, it can improve the efficacy of certain serious bacterial and viral infections.

Usage: For intramuscular injection only, not for intravenous infusion.

Dosage: 1. Prevention of measles: To prevent the onset of disease or alleviate symptoms, 0.05-0.15 ml per kg body weight can be injected within 7 days of contact with measles patients. Children under 5 years old can be injected with 1.5-3.0 ml, and the maximum injection volume for children over 6 years old should not exceed 6 ml. The preventive effect of a single injection usually lasts 2 to 4 weeks. 2. Prevention of infectious hepatitis: Inject 0.05-0.1 ml per kg body weight or 3 ml each time for adults and 1.5-3 ml each time for children. The preventive effect of one injection usually lasts about one month.

Adverse reactions: Generally no adverse reactions. A few people may experience redness, swelling and pain at the injection site, which do not require special treatment and can recover on their own.

Contraindications: 1. Those who are allergic to immunoglobulin or have other severe allergic history. 2. People with selective IgA deficiency who have IgA antibodies.

Precautions

1. This product should not be used if it is turbid, has sediment that cannot be shaken off, contains foreign matter or has cracks in the glass bottle, or is expired. 2. After opening the bottle, the drug should be injected once and should not be used in multiple injections. 3. Freezing is strictly prohibited during transportation and storage. There is fever and local pain at the injection site. Blood typing and more accurate agglutination tests should be performed before use.

Pharmacology and pharmacokinetics

Pharmacological action: Injection of immunoglobulin is a passive immunotherapy. It is a process of transferring a large amount of antibodies contained in immunoglobulin to the recipient, so that the recipient can quickly reach a temporary immune protection state from a low or no immune state. Because antibodies interact with antigens, they directly neutralize toxins and kill bacteria and viruses. Therefore, immunoglobulin products play a certain role in preventing bacterial and viral infections.

Pharmacokinetics: The biological half-life of human immunoglobulin is 16 to 24 days.

Everyone already knows something about drugs such as human immunoglobulin. Human immunoglobulin is mainly used for intramuscular injection. It is also very suitable for children as a medicine to prevent diseases such as measles. It can also be used to prevent infectious hepatitis, etc. However, the dosage for adults and children is different, so it is best to follow the doctor's advice before use.