What tumor markers are checked for liver cancer? Three tumor markers are checked for liver cancer

The commonly used tumor markers for liver cancer are as follows:

First, alpha-fetoprotein, or AFp. It is the most clinically significant liver cancer marker. The AFp positivity rate in patients with hepatocellular carcinoma is about 70%, and the AFp concentration is usually positively correlated with the size of liver cancer.

In addition, it should be noted that AFp may show false positives in genital embryonal tumors, a few metastatic tumors such as gastric cancer, and pregnant women with hepatitis and cirrhosis, but the elevated level is not as obvious as that of liver cancer.

Second, it is lambda glutamine transferase isoenzyme II, this enzyme is called GGT, GGT isoenzyme II, for the diagnosis of primary liver cancer, the most specific, with a positive rate of 90%, and a specificity of 97.1%. In addition, the level of this enzyme has nothing to do with AFp, and it will also have a higher positive rate in liver cancer with low concentration of AFp and false negative liver cancer.

Third, abnormal prothrombin Ap. Liver cancer itself has the function of synthesizing and releasing abnormal prothrombin with incomplete glutamate carboxylation. The positive rate of hepatocellular carcinoma patients is about 67%, while when benign liver disease turns into liver cancer, only a few are positive, which has early value in diagnosing subclinical liver cancer.