What complications may bile duct cancer cause?

What complications can bile duct cancer cause? Compared with other cancers, bile duct cancer is more harmful, because patients with bile duct cancer are not only vulnerable to the harm of this disease, but also cause a variety of complications, aggravating the condition and harming patients. So, what complications can bile duct cancer cause?

What are the complications of bile duct cancer?

1. Biliary fistula: Biliary fistula is the most common complication after cholangiocarcinoma surgery. It often occurs due to improper treatment of the bile duct at the liver wound after hepatectomy or anastomosis of the intrahepatic bile duct with the jejunum. Since there are many openings in the intrahepatic bile duct, the occurrence of bile fistula is reduced.

2. Massive intra-abdominal hemorrhage: It often occurs in patients with combined liver lobectomy and portal vein injury during surgery. It is also seen in bleeding from the bile-enteric anastomosis. The abdominal cavity drainage of fresh blood is >200ml/h, indicating active bleeding in the abdominal cavity.

3. Liver failure: Liver failure is a common cause of death during bile duct cancer surgery, and is more common in patients with poor liver reserve function.

4. Acute renal failure: usually secondary to severe jaundice, often due to insufficient effective circulating blood volume, sympathetic nerve excitement, increased activity of the renin-angiotensin system, decreased renal prostaglandins, increased thromboxane A2 and endotoxemia.

5. Stress ulcer bleeding: a serious complication after surgery for patients with severe obstructive jaundice. Its pathogenesis is not yet fully understood, but it is generally believed that hyperbilirubinemia and hypercholesterolemia damage the gastric mucosal barrier and reduce gastric mucosal blood flow.