Is it necessary to do non-invasive surgery for twins

Pregnant women have to bear a certain risk factor when they are pregnant. There are many aspects of this risk factor, the most important of which is whether the baby in her belly will show symptoms of chromosomal abnormalities. If the baby has chromosomal abnormalities, it may cause Down syndrome. Non-invasive DNA testing can effectively detect chromosomal abnormalities in babies, but if you are pregnant with twins, is it not necessary to do non-invasive testing?

Is it necessary to do non-invasive DNA test for twins?

It is not particularly necessary for twins to undergo non-invasive surgery, but of course it is possible. Non-invasive DNA draws blood from pregnant women, extracts free fetal DNA fragments, and combines it with bioinformatics analysis to detect the risk of chromosomal abnormalities in the fetus.

Identical twins can undergo non-invasive DNA prenatal testing. As for identical twins, because they come from the same fertilized egg, they not only have similar appearances, but also have the same blood, intelligence and even certain physiological characteristics. We may have seen conjoined twins on television. In fact, conjoined twins are also identical twins, but they are connected in some parts due to incomplete division of the fertilized egg.

However, for relatively suitable populations, the effectiveness of non-invasive DNA prenatal testing will be reduced to a certain extent and should be used with caution among pregnant women, including pregnant women carrying twins. Since the DNA of each fetus is inconsistent, there will be certain deviations in the test results.

Other groups who are not suitable for non-invasive DNA testing include: 1. Elderly pregnant women with high risk of prenatal screening, expected age of delivery ≥ 35 years, and other indications for direct prenatal diagnosis. 2. Gestational age <12 weeks. 3. Weight > 100 kg. 4. Conception through in vitro fertilization-embryo transfer (IVF-ET). 5. Suffering from malignant tumors. 6. Pregnant women with chromosomal structural abnormalities or chromosomal diseases. For example, the chromosomes of the pregnant woman herself are mosaic, translocated, microdeleted, microduplicated, etc. 7. Pregnant women who have recently received allogeneic blood transfusion, transplant surgery, or stem cell therapy will introduce exogenous DNA and affect the test results.

Advantages of non-invasive DNA testing

1. Non-invasive: Only 5 mL of maternal peripheral blood is drawn: Non-invasive prenatal genetic testing is performed by collecting 5 mL of peripheral blood from pregnant women, extracting free DNA, using a new generation of high-throughput sequencing technology, and combining it with bioinformatics analysis to derive the risk rate of the fetus suffering from chromosomal aneuploidy, which has the advantage of being non-invasive.

2. Safety: Avoid fetal intrauterine infection and miscarriage. Traditional high-risk Down syndrome screening methods such as amniocentesis are invasive diagnostic methods, which will increase the risk of fetal intrauterine infection and miscarriage. Non-invasive prenatal genetic testing uses a new generation of non-invasive characteristics, which can effectively ensure the safety of mother and child.

3. Early stage: Non-invasive prenatal genetic testing advances the time to 12 weeks, which can detect the results earlier and make corresponding countermeasures.

4. Accurate: It uses a new generation of sequencing technology with an accuracy rate of more than 99%. After rigorous testing, the detection rate is higher when the test is performed between 12 and 24 weeks of pregnancy.

The significance of non-invasive genetic testing is to avoid and reduce the birth rate of Down syndrome babies, especially for older pregnant women with higher risks. Non-invasive genetic testing technology is currently the most advanced Down syndrome screening technology in the world.