Anti-androgen drugs for the treatment of prostate cancer

Testosterone is a male hormone that promotes prostate growth, creating a good environment for the growth of prostate cancer. Some anti-androgen drugs can be used in treatment to prevent cancer cells and normal prostate tissue from being stimulated by male hormones.

The following are some commonly used anti-androgen drugs:

Cyproterone acetate: It can prevent dihydrotestosterone from binding to receptors in the cell nucleus to form a complex and inhibit the release of pituitary luteinizing hormone. The dose is 100 mg each time, orally twice a day. Adverse reactions include gynecomastia.

Chlorprogesterone acetate: It has obvious progestin and anti-androgen effects, and inhibits the secretion of testosterone by interstitial cells. The dosage is 250 mg per day orally, which is effective for most prostate cancer patients. Adverse reactions include cardiovascular and gastrointestinal reactions.

Megestrol acetate: Its effect is the same as natural progesterone, the dosage is 4 mg each time, twice a month.

Medroxyprogesterone acetate (medroxyprogesterone acetate): has central and peripheral anti-androgen effects. The dosage is 100 mg orally, 3 times a day.

Chlormadinone acetate: It can cause the prostate to shrink. It is taken orally at a dose of 100 mg per day. After 3 months, take a maintenance dose of 50 mg per day. Adverse reactions include gastrointestinal and cardiovascular reactions and loss of libido.

Flutamide: The dosage is 750 mg per day, taken in 3 divided doses after meals. The adverse reactions are minor, including diarrhea, facial fever, and breast development in men.

Ketoconazole: It is an antifungal drug. Large doses can block the synthesis of testosterone in the testicles and adrenal glands. The dosage is 200-400 mg, taken orally every 8 hours. Adverse reactions such as reversible liver damage, nausea, fatigue, and dry skin and mucous membranes may occur after taking the drug.