What causes high glutamyl transpeptidase?

Many people are not very familiar with glutamyl transpeptidase. Glutamyl transpeptidase belongs to a kind of human cell tissue and is generally more common in the human liver. When the glutamyl transpeptidase index is normal, the body is relatively healthy. If the glutamyl transpeptidase is high or too high, it will easily lead to liver disease, hepatitis and other diseases.

What causes high glutamyl transpeptidase?

First, when suffering from "acute viral hepatitis", the liver cells adjacent to the necrotic area have hypersynthesis of enzymes, which causes an increase in serum glutamyl transpeptidase. This factor is also the most common and the one that cannot be ignored.

Second, in chronic active "hepatitis", glutamyl transpeptidase is often 1-2 times higher than normal. If it remains elevated for a long time, there may be a tendency towards liver necrosis.

Third, when the intrahepatic or extrahepatic bile duct is obstructed, the excretion of glutamyl transpeptidase is blocked and refluxes into the blood with bile, resulting in elevated glutamyl transpeptidase levels.

Fourth, the glutamyl transpeptidase levels in almost all patients with alcoholic hepatitis and alcoholic cirrhosis are elevated, becoming an important feature of "alcoholic liver disease".

Fifth, in patients with primary or "metastatic liver cancer", glutamyl transpeptidase levels are mostly moderately or highly increased, which can be several times or even dozens of times higher than normal.

Sixth, in the early stages of primary or secondary "biliary cirrhosis", elevated glutamyl transpeptidase levels may also occur.

Seventh, patients with "fatty liver" may also experience elevated glutamyl transpeptidase, but in general, in cases of nutritional fatty liver, the serum glutamyl transpeptidase activity is usually no more than twice the normal value.

What should I do if glutamyl transpeptidase is elevated?

The reasons for high glutamyl transpeptidase levels in many patients are different. The doctor will determine the appropriate test based on the patient's condition. The doctor then determines the severity of the patient's condition based on the examination results, and ultimately develops a personalized treatment plan for targeted treatment.

1. High glutamyl transpeptidase caused by viral hepatitis

You need to go to a regular hospital for viral DNA and liver function tests. If it is caused by a virus, you need to receive antiviral treatment and take antiviral drugs.

2. High glutamyl transpeptidase caused by alcoholic liver or fatty liver

Patients should pay attention to daily diet adjustments, quit smoking and drinking, pay attention to rest and other matters. Western medicine currently has no drugs to prevent and treat fatty liver. It is best to use Chinese medicine for long-term conditioning and treatment, mainly focusing on protecting the liver, removing fat, anti-oxidation, and selenium supplementation.