Indications of Cyclic Adenosine Glucoamine for Injection

Cycloadenosine meglumine for injection is used as an adjuvant treatment for cardiac diseases and is a prescription drug. Cyclic adenosine meglumine for injection is a white powder medicine that can be used as an energy agent and can protect some important organs. Of course, injectable cycloadenosine meglumine also has certain adverse reactions, such as the usual simple ones we usually see, such as dizziness, nausea, etc. So how should I use cycloadenosine meglumine for injection? Let us learn about the precautions when using it!

1. Ingredients

The main ingredient of this product is cyclophosphamide

It is a salt of cyclic adenosine monophosphate and meglumine (molar ratio 1:1).

Molecular formula: C10H12N5O6P•C7H17NO5

Molecular weight: 524.42

(II) Characteristics

This product is white or off-white loose mass or powder.

3. Indications

This product can be used as an energy mixture to protect the functions of important organs and is widely used in cardiovascular diseases, respiratory diseases, nervous system diseases, surgical operations, etc. It is used for heart failure, myocarditis, sick sinus syndrome, coronary heart disease and cardiomyopathy, and can be used as an auxiliary treatment for arrhythmias.

(IV) Usage and Dosage

1. Intravenous drip: add 200-500 ml of 5% glucose injection solution to dissolve and then drip intravenously, once a day, 60-180 mg each time. 2. Intravenous push: Add 20-40 ml of 25% or 10% glucose injection solution to dissolve and slowly push intravenously, once a day, 90 mg each time.

(V) Adverse Reactions

Occasionally, symptoms such as palpitations, heart palpitations, and dizziness may occur.

(VI) Taboos

1. Those who are allergic to any ingredient in the drug. 2. This product should not be administered intravenously simultaneously with aminophylline.

(VII) Notes

1. The infusion should not be too fast. The dosage of more than 150 mg should be completed in more than 90 minutes. 2. If you experience palpitations or heart palpitations, you should stop taking the medication. The symptoms will disappear on their own after stopping the medication.

8. Pharmacology and Toxicology

Cyclic adenosine meglumine is a non-digitalis cardiotonic agent with a positive inotropic effect. It can enhance myocardial contractility, improve myocardial pump function, dilate blood vessels, and reduce myocardial oxygen consumption. It can improve myocardial cell metabolism and protect ischemic and hypoxic myocardium. It can improve the function of sinoatrial node P cells.

9. Pharmacokinetics

Cyclic adenosine phosphate meglumine enters the human body, and its half-life in the blood is 60 to 150 minutes. Due to its good hydrophilicity, especially its strong fat solubility, it can easily penetrate the fat-soluble cell membrane and enter the myocardial cells to exert its effects. It is decomposed into 5-AMP by the phosphodiester phase, and then degraded into adenosine and phosphate by the 5-AMP phase. Cyclic adenosine phosphate meglumine begins to work 10 to 20 minutes after administration, with the peak effect time being 1 to 2 hours, and the drug effect disappears in 6 to 8 hours.