Why is alkaline phosphatase high?

Friends with high alkaline phosphatase need to understand which diseases cause it. The most common ones are liver and gallbladder diseases, such as secondary liver cancer and cholestasis. If you suffer from leukemia or hyperthyroidism, your alkaline phosphatase will also be elevated.

1. Hepatobiliary diseases: obstructive jaundice, primary liver cancer, secondary liver cancer, cholestatic hepatitis, etc.

2. Because this enzyme is also very active in bone tissue. Therefore, pregnant women, fracture healing period, and osteomalacia. Serum alkaline phosphatase will increase in rickets, osteocellular carcinoma, osteoporosis, etc.

3. Serum alkaline phosphatase may also increase in leukemia and hyperthyroidism.

If conditions permit, you can do an alkaline phosphatase isoenzyme test, or ask the hospital to use a heat stability test to identify whether it comes from the liver or the bones.

4. Alkaline phosphatases are widely distributed in human tissues such as bones, liver, intestines, and placenta. It is mainly used for the examination of obstructive jaundice, primary liver cancer, secondary liver cancer, and cholestatic hepatitis. In patients with these diseases, liver cells overproduce ALP, which enters the blood through the lymphatic tract and hepatic sinusoids. At the same time, due to the obstruction of bile excretion in the intrahepatic bile duct, bile refluxes into the blood, causing a significant increase in serum alkaline phosphatase. But this enzyme is also very active in bone tissue.