What are the causes of rheumatoid arthritis

The impact of rheumatic diseases is very serious for middle-aged and elderly people. Once suffering from rheumatic diseases, patients will suffer from constant pain in their limbs in rainy weather. Severe cases may also be accompanied by gout and other diseases. Therefore, it is very necessary to prevent and treat rheumatoid diseases. First of all, we must find the cause of the disease. So, what are the causes of rheumatoid arthritis?

1. Rheumatoid disease is a chronic, systemic disease with unknown etiology, characterized by inflammatory synovitis. It is characterized by polyarticular, symmetrical, invasive arthritis of the small joints of the hands and feet, often accompanied by extra-articular organ involvement and positive serum rheumatoid factor, which can lead to joint deformities and loss of function.

2. Rheumatoid disease may be related to genetics, infection, sex hormones, etc. The pathology of RA arthritis mainly includes proliferation of synovial lining cells, infiltration of a large number of inflammatory cells in the interstitium, as well as the formation of microvessels, the formation of pannus and the destruction of cartilage and bone tissue.

The disease has an acute onset and is often preceded by a history of intestinal or urinary tract infection. The large joints (especially the joints of the lower limbs) are mainly affected asymmetrically, and small joints such as the proximal interphalangeal joints of the fingers and wrist joints are generally not affected symmetrically.

3. Before the onset of rheumatoid disease, it may be accompanied by ophthalmitis, urethritis, balanitis and fever. HLA-B27 may be positive while the rheumatoid factor is negative. Patients may have X-ray changes of asymmetric sacroiliitis. Therefore, early observation of the health of these parts has a positive significance for diagnosis.

The main purpose of rheumatoid arthritis treatment is to reduce joint inflammation, inhibit the progression of lesions and irreversible bone destruction, protect joint and muscle function as much as possible, and ultimately achieve the goal of complete remission or low disease activity.