Glioma may be related to genetics

Glioma is a type of brain cancer and a disease with a high mortality rate, which endangers human health. Most researchers are studying its cause, and some people consider it to be related to genetic factors. So could glioma be related to genetics? Let's learn about it together with the editor below.

Among all intracranial tumors, glioma accounts for about 46%, which is the most common type of brain tumor. Some families may have several glioma patients in succession. Does this mean that glioma is hereditary? So, is glioma hereditary?

At present, there is no clear evidence that gliomas are definitely hereditary, and the medical community has been debating this issue. However, a small number of brain tumors in life are indeed hereditary, that is to say, congenital brain tumors do exist, such as bilateral acoustic neuromas in multiple neurofibromatosis, which is caused by a genetic defect on a chromosome and has a genetic tendency.

It is difficult to elucidate the genetic events that underlie tumorigenesis. Even in the best-studied glioma models used to study astrocytoma progression, tumors are already low-grade, aggressive tumors (WHO grade II astrocytomas) upon initiation. It seems impossible to study true preneoplastic lesions in the field of neuro-oncology. Qualitative and quantitative abnormalities in oncogenes, tumor suppressor genes, growth factors, or growth factor receptors can promote tumor growth. Oncogenes and Tgs can become dysfunctional through point mutations, rearrangements, translocations, deletions, amplifications, and inactivation. Abnormalities in the tumor genome can result in overexpression, dysregulated expression, inactivation, or expression of abnormal proteins, which can be assessed using a variety of molecular techniques, including immunohistochemistry.

Whether glioma is hereditary still needs further medical research. If someone in your family has glioma, it is best to pay close attention to it and do regular cancer prevention checkups. There is no need to worry too much about other things.