A review of the causes of osteosarcoma

Before introducing the causes of osteosarcoma, let me first share with you what osteosarcoma is. Osteosarcoma, also known as osteogenic sarcoma, is a common malignant bone tumor that occurs in adolescents or children under the age of 20. It is the most common malignant bone tumor in children, accounting for about 5% of pediatric tumors. After understanding what osteosarcoma is, let's review the causes of osteosarcoma.

Osteosarcoma may occur for the following reasons:

1. Active growth of bones.

2. Radiation: Experiments have shown that any radioactive substance that can accumulate in the bones can induce osteosarcoma; local radiation therapy for certain bone diseases such as giant cell tumor of bone, aneurysmal bone cyst or extra-bone tumors such as breast tumor, retinoblastoma, etc. can occasionally cause secondary osteosarcoma.

3. What are the causes of osteosarcoma? Heredity: The retinoblastoma gene Rb gene is located on chromosome 13q14. It is currently known that it is a tumor suppressor gene mutation or deletion. Patients with hereditary retinoblastoma have a much higher risk of osteosarcoma than the average person. In recent years, it has been found that some osteosarcoma patients also have mutations in the Rb gene.

4. Viruses: Experiments have shown that animal osteosarcoma is related to viral infection, but there is no definite data to explain the relationship between human osteosarcoma and viruses.

5. Malignant transformation of benign bone diseases: such as multiple osteochondromas, Paget's disease of bone, fibrous dysplasia of bone, etc., which may lead to osteosarcoma, also known as secondary osteosarcoma.

The above is a brief summary of the causes of osteosarcoma. I believe everyone has a certain understanding. In addition to preventing the disease from these causes, patients should also participate in more outdoor activities and enhance their physical fitness, so as to better resist the disease and reduce unnecessary troubles.