What are the causes of bile duct cancer?

What are the causes of bile duct cancer? Biliary duct cancer seriously endangers people's health and life. The research on the cause of bile duct cancer has never stopped. Understanding the cause of the disease has important guiding significance for disease prevention. Studies have shown that the incidence of bile duct cancer is related to the following five factors. Let's take a look.

1. Chronic inflammation and infection of the bile duct: Long-term chronic inflammation is the basis for the occurrence of bile duct cancer, because clinically found that diseases related to bile duct cancer can lead to chronic inflammation of the bile duct. Certain substances in the bile, such as the metabolites of bile acid, stimulate the bile duct mucosa for a long time, leading to atypical hyperplasia of the epithelium.

2. Bile duct and gallbladder stones: 20% to 57% of bile duct cancer patients have gallstones, so it is believed that chronic stimulation by stones may be a carcinogenic factor.

3. Ulcerative colitis: It has been reported that the incidence of bile duct cancer in patients with ulcerative colitis is 10 times higher than that in the general population. The age of onset of bile duct cancer patients with ulcerative colitis is 20 to 30 years earlier than that of the general population, with an average age of 40 to 45 years. They often have a long history of colitis. Chronic bacteremia in the portal vein system of patients may be the cause of bile duct cancer and PSC.

4. Clonorchis sinensis: In Southeast Asia, eating raw fish and being infected with liver flukes can lead to bile duct infection, bile stasis, peribiliary fibrosis and bile duct hyperplasia, which is one of the factors leading to bile duct cancer. People who are used to eating foods rich in nitrites are more likely to develop cancer.

5. Cystic dilatation of the bile duct: A small number of patients with cystic dilatation of the bile duct develop cancer. The formation of stones in the cyst, bacterial infection, and especially the reflux of pancreatic juice due to abnormal development of the confluence are the main causes of cancer.

Through the above introduction, everyone has understood the cause of bile duct cancer. For bile duct cancer, only if we understand the complications well can we better prevent it, and only in this way can we ensure the health of the body.