What are the causes of skin cancer?

The main causes of skin cancer are temporary strong sun exposure, dry skin, atrophy and keratinization; chemical stimulation, I may have different understandings of the causes of skin cancer. Such as temporary contact with asphalt, coal tar or arsenic; physical stimulation, such as unstable scars, chronic ulcers and sinus tracts that do not heal for a long time; skin proliferative lesions, such as skin hyperkeratosis, mucosal leukoplakia, pigmented xeroderma, papilloma, etc. are closely related. Pathology is that squamous cell carcinoma originates from epithelial cells. Basal cell carcinoma is mainly composed of basal cells, and the characteristics are that the cancer cell nests are often branched, mostly solid, and cavities can also be seen.

Causes of Skin Cancer

① Daily exposure and ultraviolet radiation: The parts of the skin that receive the most ultraviolet radiation are the head, face, back of the neck, and hands. There is sufficient evidence to support that ultraviolet radiation, the protection of human melanin and the interaction of the immune system function lead to the occurrence of skin cancer. Human skin was measured in sunlight. Squamous cell carcinoma almost all occurs in these parts. The carcinogenic mechanism of ultraviolet rays may be that the photochemical effect changes the structure of cell DNA, destroys the active antigen structure on the surface of lymphocytes, reduces the body's immune function, and other cancer-promoting factors jointly participate in the occurrence of skin cancer.

② Chemical carcinogens: People have just discovered that workers who are frequently exposed to arsenic, tar and asphalt are prone to skin cancer. Chemical carcinogenesis can be divided into two periods, about 100 years after Percival first described the report that chimney sweeps were prone to scrotal skin cancer. That is, the initiation period and the promotion period. The results from the initiation period are closely related to the exposure to special substances or carcinogens. The progress is irreversible, and cell changes are related to genetics. The promotion period requires repeated exposure to the contact material, which is related to the interval time. If it is not exposed for a long time, it can still be reversed and no cancer will occur. The interval between the initiation period and the promotion period is very important, and there can be two results, namely the formation or non-formation of skin cancer.

③ Ionizing radiation: In recent years, due to the improvement of radiation equipment and the progress of radiation technology, skin cancer, which used to occur on the basis of radiation workers' radiation-induced dry skin due to neglect of protective measures, has basically disappeared due to the strengthening of various protective measures. However, some patients who have received radiotherapy may still develop skin cancer in the radiation field after several years.

④ Chronic soothing and inflammation: Squamous cell carcinoma is more likely to occur in the oral cavity or lips. Malignant skin tumors can occur and develop in scars, chronic ulcers, fistulas, and sinus tracts. Some Asians are addicted to chewing tobacco or betel nuts.

⑤Other immunosuppression stages: The patient's immune system is under-functioning and skin cancer may occur. For example, the use of immunosuppressants can promote the occurrence of skin cancer. Viral carcinogens, many viruses can cause cancer in animal hosts, and many human papillomavirus subtypes in humans can induce skin cancer.

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