Are there any adverse reactions to tacrolimus eye drops?

Tacrolimus eye drops are suitable for anti-allergic and spring keratitis. They can also show inflammation and achieve the effect of sterilization. This medicine should be taken about twice a day, and the first drop can be taken at a time. Do not increase the dosage, because if the dosage is increased privately or the system is not checked and the medicine is used indiscriminately, it is likely to cause some complications and may also cause vision damage. Pregnant women cannot use it, and patients who are allergic to this product cannot use it without authorization.

【 Main ingredients 】 Tacrolimus hydrate.

【 Properties 】White suspension.

[ Indications/Main Functions ] Suitable for patients with vernal keratoconjunctivitis who have not been effectively treated with anti-allergic treatment. It should be used when giant papillary proliferation of the palpebral conjunctiva is observed.

[ Specification ] 5ml

[ Usage and Dosage ] Shake well before use. Usually 1 drop is administered twice a day.

[ Adverse Reactions ] Since most users have serious illnesses and take many other drugs at the same time, it is often difficult to determine the adverse reactions associated with immunosuppressive drugs. There is evidence that many of the following adverse drug reactions are reversible and may improve with dose reduction. The frequency of adverse reactions is significantly lower with oral administration compared to intravenous administration. The following adverse drug reactions are organized according to body system and their frequency of occurrence. Cardiovascular System - Frequent: hypertension. Occasional: angina, palpitations, effusion (e.g. pericardial effusion, pleural effusion). Rare: Hypotension including shock, ECG abnormalities, arrhythmias, atrial/ventricular fibrillation and cardiac arrest, thrombophlebitis, bleeding (e.g., gastrointestinal, cerebral), heart failure, cardiomegaly, bradycardia, ventricular and/or septal hypertrophy (including cardiomyopathy).

【 Contraindications】 Pregnancy. Patients with known hypersensitivity to tacrolimus or other macrocyclic drugs. Known allergies to other ingredients. Those with known allergy to polyethylene hydrogenated castor oil (HCO-60) or similar structural compounds.

[ Precautions ] When the blood concentration of tacrolimus is maintained below 20 mg/mL, the condition of most patients can be successfully controlled. The patient's clinical condition must be considered when measuring whole blood concentrations. If the blood concentration is below the limit of quantitation determined by the quantitative assay and the patient's clinical condition is good, no dose adjustment is required. In clinical use, the whole blood trough concentration is usually 5-20 mg/mL in the first 12 hours after transplantation. Effects on the use of equipment and driving ability: Tacrolimus may interfere with the visual and nervous systems. Patients receiving tacrolimus who may be affected by the drug's interference effects should not drive or operate hazardous machinery. This interference is enhanced when tacrolimus is taken with alcohol.

[Use in children] Not yet clear.

[Use in elderly patients] Not yet clear.

[Use in pregnant and lactating women] Not yet clear.

[Drug Interactions] Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.