What is acute febrile neutrophilic dermatosis

Because acute febrile neutrophilic dermatosis is not very common in our lives, many friends do not know much about it. In fact, this is very bad, because acute febrile neutrophilic dermatosis occurs quickly, and it is very dangerous if it is not treated correctly. In order to better protect your health, this article will give you a detailed introduction to what acute febrile neutrophilic dermatosis is.

Acute febrile neutrophilic dermatosis is a painful raised erythema of the skin caused by neutrophilia and extensive infiltration of the superficial and middle layers of the dermis, accompanied by fever and damage to other organs. It is also known as Sweet syndrome. The disease usually has an acute onset, occurs more frequently in summer and autumn, and is more common in middle-aged and older women. There are often precursor symptoms such as influenza-like upper respiratory tract infection, bronchitis, tonsillitis, etc. 1-2 weeks before the onset of the disease. The disease responds well to corticosteroids, and symptoms can generally be relieved with timely and appropriate treatment.

Clinical manifestations

1. Fever, myalgia and migratory pain in large joints;

2. Early rashes are mostly exudative erythema or papules;

3. Typical skin lesions are flat, raised, multi-ring, round or oval erythema, with pseudo-blister-like granules or papillary protrusions often seen on the edges, and dark red bullae in some cases;

4. Conjunctival congestion, oral mucosal erosion and ulcer;

Diagnosis

1. Acute onset, with symptoms of upper respiratory tract infection before onset.

2. The rash may be exudative erythema, papules, and painful raised erythema.

3. The erythrocyte sedimentation rate increases and has a parallel relationship with systemic symptoms. Peripheral blood WBC>10×109/L, and the number of neutrophils increased significantly. Transient hematuria and proteinuria.

4. The tuberculin intradermal test is strongly positive.

5. Positive acupuncture reaction.

6. Histopathological examination: The upper and middle layers of the dermis and around the blood vessels showed localized dense polymorphonuclear leukocyte infiltration.

Treatment principles

1. Find and eliminate the cause of the disease and avoid various inducing factors.

2. Nonspecific anti-allergic treatment.

3. Reduce capillary permeability and fragility.

4. Treatment with corticosteroids and immunosuppressants.

5. Provide symptomatic supportive treatment.

Medication principles

1. Mild cases are mainly treated with oral vitamins C, E and moderate doses of corticosteroids.

2. For severe cases or those with other organ damage, moderate to high doses of corticosteroids are given intravenously, while supportive symptomatic treatment is also provided.

3. If the treatment with corticosteroids is ineffective, you can add 4-aminobutyric acid or 2-hydroxy-3-nitropropene tablets.

Now that we know what acute febrile neutrophilic dermatosis is, and understand the symptoms and treatment principles of the disease, I believe that all of you have sufficient understanding of the disease, and you will definitely know what to do when the disease occurs. In fact, the most important thing about acute febrile neutrophilic dermatosis is prevention. Only by doing a good job of preventing acute febrile neutrophilic dermatosis can our health not be threatened.