Is direct bilirubin 81 considered high?

Bilirubin is a very important diagnostic indicator clinically. The bilirubin value needs to be referred to when checking liver function, especially jaundice after the baby is born, which also has very important diagnostic significance. Total bilirubin is divided into direct bilirubin and indirect bilirubin. Many people are unable to understand the situation when faced with the conclusion. So, is direct bilirubin 81 considered high? Let’s take a look below.

Normal reference range of direct bilirubin

Normal reference value of serum direct bilirubin: 0～6.8μmol/L (normal 0-6.8). Direct bilirubin 81 is considered high.

Direct bilirubin (DBil), also known as conjugated bilirubin, is produced by indirect bilirubin entering the liver and combining with glucuronic acid under the action of glucuronyl transferase in the liver. Direct bilirubin is soluble in water, reacts directly with azo reagents, and can be excreted from the body through the kidneys in urine. The liver plays an important role in the metabolism of bilirubin, including the uptake, conjugation and excretion of indirect bilirubin in the blood by hepatocytes. The increase in serum direct bilirubin indicates that the excretion of bilirubin from the bile duct after processing by hepatocytes is impaired. The determination of direct bilirubin helps in the diagnosis and differential diagnosis of jaundice types.

Increased direct bilirubin: mainly seen in obstructive jaundice, hepatocellular jaundice, liver cancer, pancreatic head cancer, cholelithiasis, bile duct cancer, etc.

The differential diagnosis of jaundice types are as follows:

1. Hemolytic jaundice: After the red blood cells are destroyed, a large amount of hemoglobin enters the monocytes and macrophages and is converted into indirect bilirubin. Due to the excess of indirect bilirubin, liver cells cannot convert all of the indirect bilirubin into direct bilirubin, resulting in an increase in indirect bilirubin in the serum.

2. Hepatocellular jaundice: Liver lesions lead to a decrease in the ability of liver cells to convert indirect bilirubin, so the indirect bilirubin in the serum increases. Because of the blockage of bile duct capillaries, the excretion of direct bilirubin from the bile duct is hindered, and the direct bilirubin level in the serum will also increase.

3. Obstructive jaundice: Due to obstruction inside or outside the liver, the excretion of direct bilirubin from the bile duct is hindered and it can only enter the blood circulation, causing an increase in direct bilirubin in the serum.